4-SUBSTITUTED-CYCLOHEXYLAMINO-4-PIPERIDINYL-ACETAM

专利名称：4-SUBSTITUTED-CYCLOHEXYLAMINO-4-PIPERIDINYL-ACETAMIDE ANTAGONISTS OFCCR2

发明人：LANTER, James, C.,MARKOTAN, Thomas,

P.,SUBASINGHE, Nalin,SUI, Zhihua,ZHANG,Xuqing

申请号：EP11794348.0申请日：20111130公开号：EP2646429B1公开日：20141015

摘要：The present invention comprises compounds of Formula (I). wherein: R, R, R, R, X,Y, and Z are as defined in the specification. The invention also comprises a method ofpreventing, treating or ameliorating a syndrome, disorder or disease, wherein saidsyndrome, disorder or disease is type II diabetes, obesity and asthma. The invention alsocomprises a method of inhibiting CCR2 activity in a mammal by administration of atherapeutically effective amount of at least one compound of Formula (I).

申请人：JANSSEN PHARMACEUTICA NV

地址：BE

国籍：BE

代理机构：Carpmaels & Ransford LLP

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