Peptide nucleic acid precursors and methods of pre

专利名称：Peptide nucleic acid precursors and

methods of preparing same

发明人：Andrew P. Patron,Azra Pervin申请号：US09479320申请日：20000105公开号：US06433134B1公开日：20020813

摘要：Novel and efficient syntheses create novel piperazinone intermediates whichfacilitate the production and use of PNAs. Such syntheses and the products enhance thefeasibility of a system which permits the rapid identification of PNA oligomers useful astherapeutics, diagnostics and/or gene characterization tools. A first component of thesystem is a universal PNA library that most preferably incorporates one or moreuniversal nucleotide bases into carefully selected positions within each oligomer speciesthereby providing the library with the screening ability of a much larger library. Thesecond component of the system is a high throughput screening system that includes anumber of assays designed to provide information on the binding activities of thedifferent PNAs to a target nucleotide sequence (generally, a DNA or RNA sequence). Thethird component is a software system especially designed to provide rapid analysis of thedata collected from the high throughput screening system and to determine therefromthe sequence base identities and sequence lengths of PNA oligomers most likely to bindto and appropriately affect the target molecule.

申请人：BIOCEPT, INC.

代理机构：Fitch, Even, Tabin & Flannery

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