专利名称：METHODS AND COMPOSITIONS FOR
REPAIR OF CARTILAGE USING AN IN VIVOBIOREACTOR
发明人：Lionel C. Sevrain,Sylvie Y. Verdier- Sevrain申请号：US15371994申请日：20161207
公开号：US20170087277A1公开日：20170330
摘要：Methods and compositions for the biological repair of cartilage using a hybridconstruct combining both an inert structure and living core are described. The inertstructure is intended to act not only as a delivery system to feed and grow a living corecomponent, but also as an inducer of cell differentiation. The inert structure comprisesconcentric internal and external and inflatable/expandable balloon-like bio-polymers.The living core comprises the cell-matrix construct comprised of HDFs, for example,seeded in a scaffold. The method comprises surgically removing a damaged cartilagefrom a patient and inserting the hybrid construct into the cavity generated after theforegoing surgical intervention. The balloons of the inert structure are successivelyinflated within the target area, such as a joint, for example. Also disclosed herein aremethods for growing and differentiating human fibroblasts into chondrocyte-like cells viamechanical strain.
申请人：SpinalCyte, LLC
地址：Houston TX US
国籍：US
更多信息请下载全文后查看
因篇幅问题不能全部显示，请点此查看更多更全内容