2-Hydroxy-5-phenylazobenzoic acid derivatives and

专利名称：2-Hydroxy-5-phenylazobenzoic acid

derivatives and method of treatingulcerative colitis therewith

发明人：Rosalind P. K. Chan申请号：US06/281504申请日：19810708公开号：US04412992A公开日：19831101

摘要：The present invention provides a pharmaceutical composition for treatingulcerative colitis containing at least one compound of the general formula: ##STR1##wherein X is an --SO.sub.2 -- or --CO-- group and R is either an unsubstituted or

substituted non-heterocyclic aromatic ring system or is a radical of the general formula --(CH.sub.2).sub.n --Y, in which Y is a hydroxyl group, an unsubstituted or substituted aminogroup or a carboxylic or sulphonic acid group and n is a whole number of from 1 to 6 andin which one or more hydrogen atoms in the alkylene radical can be replaced by

unsubstituted or substituted amino groups or alkyl radicals and in which the --(CH.sub.2).sub.n --Y radical is either attached directly to the nitrogen atom or via a benzene ring;and/or containing at least one ester thereof and/or at least one non-toxic,pharmaceutically acceptable salt thereof, in admixture with a solid or liquid

pharmaceutical diluent or carrier. Furthermore, the present invention provides a processfor preparing the compounds of the above- given general formulae and also provides amethod of treating ulcerative colitis.

申请人：BIOREX LABORATORIES LIMITED

代理机构：Wenderoth, Lind & Ponack

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